✦ LIBER ✦
Intramolecular reactions of acyclic n-acyliminium ions III silicon assisted cyclocondensation of glyoxylic esters to proline and pipecolic acid derivatives
✍ Scribed by Hendrik H Mooiweer; Henk Hiemstra; Hendrikus P Fortgens; W.Nico Speckamp
- Book ID
- 104227227
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 267 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Cyclizations of acyclic N-acyliminium ions, generated from the adducts of formaldehyde, n-butyl glyoxylate or methyl glyoxylate with amines containing an ally1 or propargyl silane as terminator, lead to 3-ethenyl and 3-ethenylidene substituted pyrrolidines and piperidines, some of which are structurally related to proline and pipecolic acid.