Intramolecular Opening of β-Lactams with Amines as a Strategy Toward Enzymatically or Photochemically Triggered Activation of Lactenediyne Prodrugs.

Intramolecular Opening of β-Lactams with

Intramolecular Opening of β-Lactams with Amines as a Strategy Toward Enzymatically or Photochemically Triggered Activation of Lactenediyne Prodrugs

✍ Luca Banfi; Giuseppe Guanti; Marcello Rasparini 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB

## Abstract In order to develop a general strategy for selective activation of designed enediyne prodrugs belonging to the “lactenediyne” family, we studied the scope of intramolecular transamidation of simple monocyclic β‐lactams bearing a tethered amine. The effect of substituents, of reaction me

Intramolecular Opening of β-Lactams with Amines as a Strategy Toward Enzymatically or Photochemically Triggered Activation of Lactenediyne Prodrugs.

✦ Synopsis

Abstract