A stereocontrolled synthetic approach to E-and Z-substituted methylene-3,4-dihydro-2H-1-benzopyrans 5 is described from acyclic derivatives using as a key step the palladium-catalyzed intramolecular cyclic carbopalladation of iodoalkynes 4 followed by a carbonylation or a hydride ion capture process
✦ LIBER ✦
Intramolecular cyclization of Z,E,E-1,5,9,-cyclododecatriene by the Cp2TiCl2−LiAlH4 system
✍ Scribed by Antropiusová, H. ;Mach, K. ;Hanuš, V. ;Tureček, F. ;Sedmera, P.
- Book ID
- 112689347
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 130 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0133-1736
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## Abstract Cyclization of ethyl (__E__)/(__Z__)‐[2‐(1‐cyclohexen‐1‐yl)cyclohexylidene]cyanoacetate (2) in cold concentrated sulfuric acid affords 10‐amino‐1,2,3,4,5,6,7,8‐octahydrophenanthrene‐9‐carboxylic acid (4) and 3,5,6,7,8,8a‐hexahydro‐3‐oxospiro‐[1__H__‐2‐benzopyran‐1,1′‐cyclohexane]‐4‐carb