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Intrahepatic cholestasis of pregnancy and bile acid levels

✍ Scribed by Loïc Sentilhes; Eric Verspyck; Horace Roman; Loïc Marpeau

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
54 KB
Volume
42
Category
Article
ISSN
0270-9139

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✦ Synopsis

life-years than treatment according to "wait and see" strategy, depending on overall pancreatitis incidence (assumed to be 0.05%, 0.1%, 0.15%, or 0.2%/year) 3-5 and pancreatitis mortality (assumed to be 2.5%, 5%, 7.5%, or 10%). [6][7][8] In 6 of 16 possible scenarios, mortality during 10 years' follow-up proved to be reduced, but only in 4 of 16 possible scenarios life-years were gained by prophylactic cholecystectomy, because surgical death occurs early, whereas gained lives occur later. Further data on incidence and subsequent mortality of pancreatitis (as well as other complications) in asymptomatic gallstone carriers are clearly needed, and further cost-benefit analyses with full-scale economic evaluations are required to determine total costs and potential benefits of prophylactic cholecystectomy versus "wait and see" strategy in the different scenarios.

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