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Intragastric self-administration of medazepam in rats

✍ Scribed by K. Gunnar Götestam

Publisher
Springer
Year
1973
Tongue
English
Weight
391 KB
Volume
28
Category
Article
ISSN
0033-3158

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✦ Synopsis

A technique for intragastric self-administration in rats is presented. Intravenous self-administration of morphine was compared with intragstric self-administration during 6 consecutive days. There was no difference between the two routes in the total rate of injections.

Medazepam was given for intragastric self-administration at three different doses (2.5, 5.0 and 10.0 mg/kg/injection respectively) and compared with saline.

There was an increased response rate at the dose 10 mg/kg/injection.

Medazepam placebo solution (solvent alone) was also compared with medazepam 10 mg/kg/injeetion. Among the seven experimental ra~, six responded higher on medazepam than on the solvent.

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