✦ LIBER ✦

Intracranial volume in mild cognitive impairment, Alzheimer's disease and vascular dementia: evidence for brain reserve?

✍ Scribed by Henrike Wolf; Per Julin; Hermann-Josef Gertz; Bengt Winblad; Lars-Olof Wahlund

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 166 KB
Volume: 19
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1205

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objective

The possibility of brain volume reserve effects was examined in a sample of geriatric outpatients with mild cognitive impairment (MCI), Alzheimer's disease (AD) and vascular dementia (VaD). The total intracranial volume (ICV) served as an estimate of the maximum attained brain volume in life.

Methods

Subjects (n = 181, mean age 60.7) were consecutive referrals to a geriatric outpatients clinic (n = 96) and a group of age‐matched healthy control subjects (n = 85). ICV and brain volume were attained from T1‐weighted magnetic resonance images using a stereological method. Hippocampal atrophy was assessed with a visual rating scale.

Results

ICV was significantly smaller in patients with AD and VaD than in control subjects, but effect size was small. After adjusting for age and gender, having ICV in the smallest quartile significantly increased the risk of cognitive impairment (either MCI or dementia). In patients with dementia, but not in MCI, severity of cognitive impairment and ICV were moderately correlated. The effect of ICV on cognition was not mediated by hippocampal atrophy.

Conclusions

These findings are compatible with volume reserve effects that modify the clinical expression of symptoms in both AD and VaD. They may have implications for the design of neuroimaging studies that use ICV for normalization procedures. Copyright © 2004 John Wiley & Sons, Ltd.

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