Abstract
BACKGROUND
The current retrospective study was undertaken to evaluate the treatment outcomes of patients with meningeal hemangiopericytoma (MβHPC), to define the role of radiotherapy in the management of the disease, and to report on the patterns of failure.
METHODS
The medical records of 29 patients with nonmetastatic MβHPC treated at The University of Texas M. D. Anderson Cancer Center (Houston, TX) between August 1979 and March 1999 were reviewed. Fifteen patients (52%) underwent macroscopic total resection (βgross total resectionβ [GTR]), 10 (34%) underwent subtotal resection (STR), and 4 (14%) had unknown extent of surgery. Ten of 24 patients received adjuvant radiotherapy.
RESULTS
The 5, 10, and 15βyear overall survival rates were 85%, 68%, and 43%, respectively. The local control rates at 5 and 10 years were 68% and 22%, respectively. Two patients experienced disease recurrence at another intracranial site. Sixteen patients (55%) developed extraneural metastases. Four patients (14%) developed spinal metastases. The 5β, 10β, and 15βyear distant metastasisβfree survival rates were 80%, 46%, and 21%, respectively. The 5βyear local control rates for patients treated with GTR and STR were 84% and 38%, respectively (P = 0.003). Of the 15 patients treated with GTR, 3 received adjuvant radiotherapy as part of their initial treatment. Malignant disease did not recur locally in these three patients. However, the effect of the adjuvant radiotherapy on local control was not statistically significant.
CONCLUSIONS
MβHPCs can recur locally or distantly in the neural axis or as extraneural distant metastases. Based on literature review and the patterns of failure in the current series, attempting to perform GTR followed by limitedβfield radiotherapy appeared to represent a reasonable approach for the initial management of MβHPC. Cancer 2004;100:1491β7. Β© 2004 American Cancer Society.