Intracellular Processing of Talin Occurs within Focal Adhesions
✍ Scribed by Léone Tranqui; Marc R. Block
- Book ID
- 115601972
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 674 KB
- Volume
- 217
- Category
- Article
- ISSN
- 0014-4827
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## Abstract The formation of focal adhesions that mediate alterations of cell shape and movement is controlled by a mechanochemical mechanism in which cytoskeletal tensional forces drive changes in molecular assembly; however, little is known about the molecular biophysical basis of this response.
The rheology of cells and sub-cellular structures, such as focal adhesions, are important for cell form and function. Here we describe electromagnetic pulling cytometry (EPC), a technique to analyze cell rheology by applying dynamic tensional forces to ligand-coated magnetic microbeads bound to cell