Intracellular perfusion of cyclic AMP decreases the sodium current of guinea pig ventricular myocytes
β Scribed by Hikaru Muramatsu; Tatsuto Kiyosue; Makoto Arita
- Book ID
- 118414578
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 257 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1558-3597
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## Abstract We investigated the potential involvement of peroxynitrite (ONOO^β^) in the modulation of calcium current (I~Ca~) in guinea pig ventricular myocytes with the wholeβcell patch clamp technique and with cyclic AMP (cAMP) measurements. Because of the short halfβlife of ONOO^β^ at physiologi
We investigated the effects of the purified catalytic subunit (C subunit) of the cAMP-dependent protein kinase (A-kinase) on the cardiac Na+ channel currents. Single Na+ channel currents in guinea-pig ventricular myocytes were recorded using the patch clamp technique of the inside-out configuration.