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Intracellular NAD + depletion induces autophagic death in multiple myeloma cells

✍ Scribed by Cea, Michele; Cagnetta, Antonia; Patrone, Franco; Nencioni, Alessio; Gobbi, Marco; Anderson, Kenneth C.


Book ID
118249056
Publisher
Landes Bioscience
Year
2013
Tongue
English
Weight
975 KB
Volume
9
Category
Article
ISSN
1554-8627

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## Abstract Previous studies reported that high levels of nitric oxide (NO) induce apoptotic cell death in osteoblasts. We examined molecular mechanisms of cytotoxic injury induced by sodium nitroprusside (SNP), a NO donor, in both glutathione (GSH)‐depleted and control U2‐OS osteoblasts. Cell viab