𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106–126

✍ Scribed by Stefano Thellung; Tullio Florio; Alessandro Corsaro; Sara Arena; Massimo Merlino; Mario Salmona; Fabrizio Tagliavini; Orso Bugiani; Gianluigi Forloni; Gennaro Schettini

Book ID
117563426
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
631 KB
Volume
18
Category
Article
ISSN
0736-5748

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Study on the toxic mechanism of prion pr
Study on the toxic mechanism of prion protein peptide 106–126 in neuronal and non neuronal cells
✍ Ingrid Dupiereux; Willy Zorzi; Walid Rachidi; Danièle Zorzi; Olivier Pierard; Be 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 591 KB

## Abstract A synthetic peptide corresponding to the 106–126 amyloidogenic region of the cellular human prion protein (PrP^c^) is useful for in vitro study of prion‐induced neuronal cell death. The aim of the present work was to examine the implication of the cellular prion protein in the toxicity

Prion protein fragment 106–126 induces a
Prion protein fragment 106–126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line
✍ Tullio Florio; Stefano Thellung; Carolina Amico; Mauro Robello; Mario Salmona; O 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB 👁 1 views

The prion diseases are transmissible neurodegenerative pathologies characterized by the accumulation of altered forms of the prion protein (PrP), termed PrP Sc , in the brain. Previous studies have shown that a synthetic peptide homologous to residues 106-126 of PrP (PrP 106-126) maintains many char