✦ LIBER ✦

Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

✍ Scribed by A. Zaza; G. Maccaferri; M. Mangoni; D. DiFrancesco

Publisher: Springer
Year: 1991
Tongue: English
Weight: 213 KB
Volume: 419
Category: Article
ISSN: 0031-6768
DOI: 10.1007/bf00370312

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✦ Synopsis

A study on the cardiac pacemaker current if in inside-out macro-patches of sino-atrial (SA) node cells has recently demonstrated that if channels are directly activated by intracellular cAMP. Using the same preparation, here we investigate the possibility that internal Ca2+ ions play a role in the modulation of if channels. Our results indicate that Ca2+ ions do not have a direct activating effect on if.