In smooth muscle cells, various transient, localized [Ca(2+)] changes have been observed that are thought to regulate cell function without necessarily inducing contraction. Although a great deal of effort has been put into detecting these transients and elucidating the mechanisms involved in their
Intracellular Ca2+ and Ca2+-Binding Proteins in Chemically Transformed Rat Fibroblasts
โ Scribed by Marianne Klug; Janaki K. Blum; Qunrui Ye; Martin W. Berchtold
- Book ID
- 115601791
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 321 KB
- Volume
- 213
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Ca^2+^ signaling pathways are well studied in cardiac myocytes, but not in cardiac fibroblasts. The aim of the present study is to characterize Ca^2+^ signaling pathways in cultured human cardiac fibroblasts using confocal scanning microscope and RTโPCR techniques. It was found that spo
The transformation of certain cells reduces the requirement of extracellular Ca'+ for growth. The SV-40 transformed human lung fibroblasts, WI-38 VA13, require less Ca" than normal WI-38 cells. Spreading area of the normal cells decreases when cultured in 1 0 p M Ca2+ medium. lntracellular calcium c