Intracellular application of hairpin ribozyme genes against hepatitis B virus
β Scribed by Welch, P J; Tritz, R; Yei, S; Barber, J; Yu, M
- Book ID
- 110038029
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 591 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0969-7128
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We have studied antibodies (anti-pol antibody) against the polymerase gene product of hepatitis B virus by solid-phase enzyme immunoaseay using synthetic peptides coded for by this gene. Sera from six patients with acute hepatitis B, 112 chronic hepatitis B virus carriers and six healthy individuals
## Abstract ## Background RNA interference based therapeutic approaches hold promise for the treatment of patients chronically infected with hepatitis B virus (HBV). To conquer HBV infection, longβterm suppression of target transcripts in all hepatocytes without toxic effects may be required. The