Intracellular accumulation of thallium as a marker of cisplatin cytotoxicity in nonsmall cell lung carcinoma : An application of inductively coupled plasma mass spectrometry
✍ Scribed by Taro Hanada; Hiroshi Isobe; Takeshi Saito; Shigeaki Ogura; Hironori Takekawa; Kohichi Yamazaki; Yoshio Tokuchi; Yoshikazu Kawakami
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 105 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND. Tl) scintigraphy has been used to detect malignant pulmonary disease. The mechanism of Tl influx in tumor cells is believed to be similar to that of cisplatin (CDDP) mediated by sodium-and potassium-activated adenosine triphosphatase (Na-K ATPase), and the Na-K ATPase activity may determine the cellular CDDP accumulation and sensitivity to CDDP. The objective of this study was to determine the accumulation of CDDP and Tl in vitro by using inductively coupled plasma mass spectrometry (ICP-MS), a new analytic technique for detecting ultra trace elements, and to evaluate the correlations between cellular CDDP and Tl accumulation, between CDDP 50% inhibitory concentration (IC 50 ) values and cellular CDDP accumulation, and between CDDP IC 50 values and cellular Tl accumulation.