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Intracellular accumulation of cholesteryl esters suppresses production of lipopolysaccharide-induced interleukin 1 by rat peritoneal macrophages

โœ Scribed by Yoshio Haga; Kyoko Takata; Norie Araki; Kiyoshi Sakamoto; Masanobu Akagi; Yoshimasa Morino; Seikoh Horiuchi


Book ID
115762495
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
400 KB
Volume
160
Category
Article
ISSN
0006-291X

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Eicosapentaenoic acid inhibits cholester
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We found that rat peritoneal macrophages bind acetyl low density lipoprotein (AcLDL) by a saturable and specific manner and accumulate a substantial amount of cholesteryl ester (CE) when incubated with AcLDL. In macrophages enriched with eicosapentaenoic acid (EPA) by the ingestion of highly purifie