Intra-Accumbens trh prolongs maintenance of tolerance to hypothermic effect of ethanol in rats

✍ Scribed by O. Pucilowski; E. Trzaskowska; W. Kostowski

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 294 KB
• Volume: 3
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.470030111

✦ Synopsis

Tolerance to the hypothermic effect of ethanol (Et-OH) developed in male Wistar rats treated daily with 5g/kg of 20 per cent ET-OH vjv i.g. for 6 days. On Day 6 Et-OH treatment was discontinued and the animals were divided into two groups injected into the nucleus accumbens septi (NAS), either with pGlu-His-Pro-NHz (TRH) or saline. The peptide was injected via permanently implanted cannulae in doses of 10 or 30 pg in 0 . 5 ~1 on each side once daily. The effect of such treatment on the maintenance of Et-OH tolerance was assessed by measuring the temperature decrement in response to a challenge dose of Et-OH (5g/ kg i.p.) given on Day 10. It was found that in saline-treated rats the initial tolerance declined. TRH-injected groups exhibited constantly low response to hypothermic action of Et-OH. In a control experiment TRH was shown to have no effect on the body temperature after intra-accumbens application in Et-OH-naive rats.