𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Intestinal perforation associated with indomethacin treatment in premature infants

✍ Scribed by G. Kühl; L. Wille; M. Bolkenius; H. W. Seyberth

Publisher
Springer
Year
1985
Tongue
English
Weight
511 KB
Volume
143
Category
Article
ISSN
0340-6997

No coin nor oath required. For personal study only.

✦ Synopsis

Within 9 months we observed intestinal perforations in three very low birth weight (VLBW) infants undergoing indomethacin treatment for symptomatic patent ductus arteriosus (sPDA). The three patients exhibited striking similarities in their clinical courses and predisposing factors. Although clinical and histological criteria did not differentiate the perforations from necrotising enterocolitis (NEC), a well-known entity in premature infants, these events were remarkable to us since we had observed no other cases of NEC in recent years. From animal experiments and pathophysiological data, a role for indomethacin in gastrointestinal ischaemic damage must be considered. This communication is not meant to discredit indomethacin treatment. However, awareness of potential complications and careful monitoring during treatment is warranted.

📜 SIMILAR VOLUMES

Retrolental fibroplasia in premature inf
Retrolental fibroplasia in premature infants with patent ductus arteriosus treated with indomethacin
✍ R. Lindemann; W. Blystad; K. Egge 📂 Article 📅 1982 🏛 Springer 🌐 English ⚖ 280 KB

Sixteen premature infants were treated with indomethacin, either orally or intravenously, in order to close a symptomatic patent ductus arteriosus requiring mechanical ventilation. Positive effect was obtained in 4 of the 10 orally treated patients and in 1 of the 6 with intravenous administration.