The effects of 2, 3,5,6,11,11 b-hexahydro-11, 11 b-dimethyl-14-indolizino(8,7,b)indole hydrochloride on intestinal motility were investigated. The indole derivative altered contractile activity in each preparation studied. Intestinal contractions in situ in anesthetized dogs were stimulated, but variable mild stimulatory or inhibitory effects occurred in cats and monkeys. Spontaneous contractions of monkey intestine were inhibited in uitro. Dose-related increases in motility were produced in dog intestine in uitro, although the experimental compound was considerably less potent than morphine as an intestinal stimulant. The stimulatory effects of the indole derivative in dog intestine were antagonized by atropine and by cyproheptadine. Indolazinoindole also inhibited propulsion of a test meal in mice in uiuo.
Keyphrases 2,3,5,6,11,llb-Hexahydro-ll,llb-dimethyl-14-indo1izino(8,7,b)indole hydrochloride-intestinal motor effects studied in cats, dogs, and monkeys Analgesics, investigational indolazinoindole-effects on intestinal motility investigated Indole derivatives-intestinal motility effects of investigational indolazinoindole studied in cats, dogs, and monkeys Intestinal motility -effects of indolazinoindole analgesic in cats, dogs, and monkeys * Merck. Sharp and Dohme.