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Intestinal Lymphatic Transport of Halofantrine Occurs After Oral Administration of a Unit-Dose Lipid-Based Formulation to Fasted Dogs

✍ Scribed by Shui-Mei Khoo; David M. Shackleford; Christopher J. H. Porter; Glenn A. Edwards; William N. Charman

Book ID: 111553147
Publisher: Springer US
Year: 2003
Tongue: English
Weight: 86 KB
Volume: 20
Category: Article
ISSN: 0724-8741
DOI: 10.1023/a:1025718513246

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The highly lipid soluble, free-base form of halofantrine (Hf base; $ 50 mg/ mL in triglyceride lipids), a highly lipophilic (calculated log P $ 8.5) antimalarial, has recently been shown to undergo signi®cant intestinal lymphatic transport (54% of administered dose) after postprandial administration