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Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning

✍ Scribed by Iliev, I D; Mileti, E; Matteoli, G; Chieppa, M; Rescigno, M

Book ID
120231940
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
507 KB
Volume
2
Category
Article
ISSN
1933-0219

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## Abstract The gut is home to a large number of Treg, with both CD4^+^ CD25^+^ Treg and bacterial antigen‐specific Tr1 cells present in normal mouse intestinal lamina propria. It has been shown recently that intestinal mucosal DC are able to induce Foxp3^+^ Treg through production of TGF‐β plus re