The genetic predisposition to deregulated mucosal immune responses and the concurrent prevalence of certain environmental triggers in developed countries are strong etiologic factors for the development of inflammatory bowel diseases in human subjects, including Crohn's disease and ulcerative coliti
Intestinal epithelial cell signalling and chronic inflammation: From the proteome to specific molecular mechanisms
β Scribed by Tanja Werner; Dirk Haller
- Book ID
- 113809070
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 867 KB
- Volume
- 622
- Category
- Article
- ISSN
- 0027-5107
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## Abstract Inflammation induces the NFβΞΊB dependent protein A20 in human renal proximal tubular epithelial cells (RPTEC), which secondarily contains inflammation by shutting down NFβΞΊB activation. We surmised that inducing A20 without engaging the proβinflammatory arm of NFβΞΊB could improve outcom