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Intestinal absorption of octreotide: N-trimethyl chitosan chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo

✍ Scribed by M. Thanou; J. C. Verhoef; P. Marbach; H. E. Junginger


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
180 KB
Volume
89
Category
Article
ISSN
0022-3549

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Effects of N-trimethyl chitosan chloride
✍ Wen He; Yumin Du; Wenbing Dai; Yan Wu; Mian Zhang πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 187 KB

## Abstract __N__‐trimethyl chitosan chloride (TMC), with degree of quaternization (DQ) of 42.77% (TMC40) and 63.03% (TMC60), respectively, were synthesized and used as absorption enhancers in an insulin rectal liquid suppository from poloxamers. The effects of the TMCs on the liquid suppository we