Intestinal absorption of copper and zinc after dietary depletion

✍ Scribed by M. Kirchgessner; F.J. Schwarz; E. Grassmann

• Book ID: 104106010
• Publisher: Elsevier Science
• Year: 1973
• Weight: 530 KB
• Volume: 2
• Category: Article
• ISSN: 0006-3061
• DOI: 10.1016/s0006-3061(00)80253-7

✦ Synopsis

Studies on the absorption of copper and zinc after dietary depletion were mnducted in v&-o with isolated everted saca of rats. In two experiments the animals were depleted with a diet low in copper (about 1 H Cu/g). The mntro1 animaIs received the same food containing Xl PM Cu/kg. Everted sacs isolated from all animals were placed into mu4 solutions with 103 M CuSO' (Experiment 1) or Cu(gIy)i (&periment 2) per liter.

The Cu transfer to the serosal soIution was significantly higher for all intestinal segments of Cu-depleted rats than for those of Cu-supplied animals (P < 0.05). With the addition of C&O' the Cu uptake by the depIeted in&stinal wall was also clearly higher than that by the intestinal wall of Cu-supplied animakz (P < 0.05). In the experiment with the Cu(gly)* solution, the Cu uptake by the intestinal wall did not differ between depk tion and control groups.

In a further experiment rati were Zn-depleted. The diet of the depletion group contained about 2 Irg Zn/g; that of the control animals w&h were fed ad Zibiium or pair-fed contained 25 a Zn/g, 10-a M Z&Q4 were added per liter of mucosal solution. The Zn depletion increased the Zn transfer to the serosal solution. Thus the Zn concentration in the serosal solution and also the Zn content in the serosal solution expressed per g of dry matter of the inkstinal wall wss significantly higher for depleted animals than for segments of Zn-supplied rats (P < 0.05). The Zn uptake by the intestinal wall per g of dry matter was also signicantIy higher for depleted animals than for the controls (P < 0.001).