Intestinal absorption of aluminum in rats: Effect of intraluminal pH and aluminum concentration

✍ Scribed by Gijsbert B. van der Voet; Frederik A. de Wolff

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 428 KB
• Volume: 6
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550060108

✦ Synopsis

The intestinal absorption of aluminum (Al) was studied in an in si?u perfusion system of rat small intestine in combination with systemic and portal blood sampling. The jejunum-ileum was perfused with media containing 4.63, 9.25 and 18.50mmoll-' A1 chloride at pH 4.0 and 7.0. Both mucosal retention and release of A1 into the blood increased at increasing perfusate concentrations. Mucos'al retention was not affected by pH but at lower pH more A1 was released into the blood. The amount of A1 which appeared in the blood was linearly related to the mucosal retention. The A1 release into the blood was much less (pmol I-') than the mucosal retention (mmol 1-I). It is concluded that the intestinal absorption of A1 is pH-and concentrationdependent.