Amiodarone is a widely used antiarrhythmic agent with highly variable therapeutic eects. These seem to be related, at least in part, to the pharmacokinetics of the drug and particularly to some features of its gastrointestinal absorption process. The drug exhibits physico-chemical properties highly
Intestinal absorption and metabolism of chlorpheniramine enantiomers in rat
✍ Scribed by Bui Tung Hiep; Christine Fernandez; Michel Tod; Hélène Banide; Alain Thuillier; Bernard Lacour; Robert Farinotti; François Gimenez
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 155 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0899-0042
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Biliary clearance (C1, ) of sotalol (STL) enantiomers was assessed in anaesthetized Sprague-Dawley rats (419 f 9 g, mean f SEM, n = 4) following administration of a 10mgkg-' IV dose of the racemate. C1b for S-and R-STL (0~0675f0~0090 and 0.0662 +\_0.0089 mL min-' kg-I, respectively) represented appr
The absorption of water from the rat small intestine during drug absorption experiments was studied. The data indicated that approximately 4 ml. of water was lost from the intestine during 60 min. Keyphrases 0 Drug absorption4oncurrent loss of water, in rat intestine Water absorption, rat intestin