Interview with the retinoblastoma family members: Do they help each other?

✍ Scribed by Tiziana Tonini; Christina Hillson; Pier Paolo Claudio

• Book ID: 102307931
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 322 KB
• Volume: 192
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.10117

✦ Synopsis

Abstract

The ultimate destiny of a cell to undergo division, differentiation, survival, and death results from an intricate balance between multiple regulators including oncogenes, tumor suppressor genes, and cell cycle associated proteins. Deregulation of the cell cycle machinery switches the phenotype from a normal cell to a cancerous cell. Fundamental alterations of tumor suppressor genes may result in an unregulated cell cycle with the accumulation of mutations and eventual neoplastic transformation. As such, one may define cancer as a genetic disease of the cell cycle. In this review, we will emphasize our current understanding of how the cell cycle machinery maintains cellular homeostasis by studying the consequences of its deregulation. © 2002 Wiley‐Liss, Inc.