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Intervertebral Disc Degeneration: Preliminary Studies of the Pathological Features of 42 Surgical Specimens

โœ Scribed by F. Valenza; M.-T. Capucchio; S. Amedeo; F. Sammartano; S. Mioletti; A. Valazza


Book ID
113695920
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
63 KB
Volume
143
Category
Article
ISSN
0021-9975

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## Abstract A significant biochemical change that takes place in intervertebral disc degeneration is the loss of proteoglycans in the nucleus pulposus. Proteoglycans attract fluid, which works to reduce mechanical stresses in the solid matrix of the nucleus and provide a hydrostatic pressure to the