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Intertwined dimeric structure for the SH3 domain of the c-Src tyrosine kinase induced by polyethylene glycol binding

✍ Scribed by Ana Cámara-Artigas; José M. Martín-García; Bertrand Morel; Javier Ruiz-Sanz; Irene Luque


Book ID
113621223
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
442 KB
Volume
583
Category
Article
ISSN
0014-5793

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The recognition of proline-rich ligands by SH3 domains is part of the process leading to diseases such as cancer or AIDS. Understanding the molecular determinants of the binding affinity and specificity of these interactions is crucial for the development of potent inhibitors with therapeutic potent