Interstitial laser coagulation: Evaluation of the effect of normal liver blood perfusion and the application mode on lesion size
✍ Scribed by Albrecht, D.; Germer, C. T.; Isbert, C.; Ritz, J. P.; Roggan, A.; Müller, G.; Buhr, H. J.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 373 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0196-8092
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✦ Synopsis
Background and Objective:
The effect of temporarily interrupted hepatic blood flow and multiple-fiber application on necrosis volume in interstitial laser coagulation (ILC) was investigated. Study Design/Materials and Methods: Single-and multiple-fiber ILC were performed in porcine livers with normal as well as interrupted perfusion. Temperatures were determined. Lesions were measured and studied by light microscopy 4 hours posttreatment. Results: ILC with multiple-fiber application led to significantly greater individual lesion volumes (3.7 ± 0.5 cm 3 ) than singlefiber application (2.5 ± 0.5 cm 3 ) (P < .01). The interruption of hepatic perfusion led to a significant increase in lesion volume with single-(7.5 ± 1.0 cm 3 ) as well as multiple-fiber application (12.6 ± 2.2 cm 3 ) (P < .01). Superposition of the lesions in the multiple-fiber application mode was only determined with interrupted perfusion (total volume: 50.3 ± 6.6 cm 3 ). Conclusion: Interruption of hepatic perfusion increases lesion volumes significantly. ILC for treating liver tumors should preferably be performed by application routes that permit temporary interruption of hepatic perfusion.