Interstitial cells of Cajal in the urethra as effectors of the nitric oxide action through the cyclic GMP pathway
β Scribed by Angeles Garcia-Pascual; Maria Sancho; Gonzalo Costa; Domingo Triguero
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 626 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2210
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π SIMILAR VOLUMES
Nitric oxide (NO) is a membranepermeant signaling molecule which activates soluble guanylyl cyclase and leads to the formation of cyclic GMP (cGMP). The NO/cGMP signaling system is thought to play essential roles during the development of vertebrate and invertebrate animals. Here, we analyzed the ce
Ca2+ entry induced by N-methyl-D-aspartate (NMDA) in neurons and by noradrenaline (NA) in astrocytes is known to increase intracellular cyclic GMP (cGMP) levels through stimulation of the Ca2+-dependent nitric oxide synthase type I (NOS-I). The possibility that Ca2+ entry could also down-regulate in