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Interstitial and large chromosome 1p deletion occurs in localized and disseminated neuroblastomas and predicts an unfavourable outcome

✍ Scribed by Achille Iolascon; Crocifissa Lo Cunsolo; Lucia Giordani; Roberto Cusano; Katia Mazzocco; Martina Boumgartner; Paola Ghisellini; Maria Felicia Faienza; Luca Boni; Bruno De Bernardi; Massimo Conte; Giovanni Romeo; Gian Paolo Tonini


Book ID
117469107
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
370 KB
Volume
130
Category
Article
ISSN
0304-3835

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## Abstract To narrow down the putative tumor‐suppressor gene locus and to assess the predictability of clinical courses by genomic alterations, we analyzed 46 oligodendroglial tumors for loss of heterozygosity (LOH) in the distal region of the short arm of chromosome 1. LOH at 1p was found in 43 t