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Interspecies variability in mitoxantrone metabolism using primary cultures of hepatocytes isolated from rat, rabbit and humans

✍ Scribed by Bruno Richard; Gérard Fabre; Georges De Sousa; Isabelle Fabre; Roger Rahmani; Jean-Paul Cano

Book ID
115782318
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
803 KB
Volume
41
Category
Article
ISSN
0006-2952

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Isolated hepatocyte cultures have become a frequently used model system for investigating drug metabolism. Although rat and hamster hepatocytes are frequently used for this purpose, metabolism in these species differs in many respects from human metabolism. A species with a metabolism more closely r