✦ LIBER ✦

Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics

✍ Scribed by Soo K. Bae; Shin J. Lee; Yoon G. Kim; So H. Kim; Jin W. Kim; Taekrho Kim; Myung G. Lee

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 192 KB
Volume: 26
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.437

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Interspecies pharmacokinetic scaling of

Interspecies pharmacokinetic scaling of BSH in mice, rats, rabbits, and humans

✍ Samir C. Mehta; D. Robert Lu 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 487 KB 👁 1 views

Interspecies pharmacokinetic scaling of

Interspecies pharmacokinetic scaling of a new carbapenem, DA-1131, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics

✍ So H. Kim; Won B. Kim; Myung G. Lee 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 2 views

The total body clearance (CI), renal clearance (CIr), and apparent volume of distribution at steady state (Vss) of DA-1131, a new carbapenem, after intravenous (iv) administration of the drug, 50 mg kg-1, to mice, rats, rabbits, and dogs were analysed as a function of species body weight (W) using t

Interspecies pharmacokinetic scaling of

Interspecies pharmacokinetic scaling of DA-8159, a new erectogenic, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics

✍ Hyun J. Shim; Yu C. Kim; Joo H. Lee; Jong W. Kwon; Won B. Kim; Yoon G. Kim; So H 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 1 views

Time-averaged total body clearance (Cl) and apparent volume of distribution at steady state (V SS ) of DA-8159 after intravenous administration to mice (30 mg/kg), rats (30 mg/kg), rabbits (30 mg/kg) and dogs (3 mg/kg) were analysed as a function of species body weight (W) using the allometric equat

Pharmacokinetics of the inodilator XB513

Pharmacokinetics of the inodilator XB513 in mice, rats, guinea pigs, rabbits, dogs, and monkeys

✍ H. F. Stampfli; C. R. Person; S.-M. Huang; C. Y. Quon 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 260 KB 👁 1 views

Pharmacokinetics of halofantrine in the

Pharmacokinetics of halofantrine in the rat: stereoselectivity and interspecies comparisons

✍ Dion R. Brocks; Jason W. Toni 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 2 views

The antimalarial drug, halofantrine, is chiral and is administered clinically as the racemate. In order to define the pharmacokinetic properties of halofantrine enantiomers in the rat, male Sprague-Dawley rats (264-311 g) were given halofantrine HCl orally (n = 5; 14 mg/kg) or intravenously (i.v.) (

Plasma protein binding of celecoxib in m

Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human

✍ Susan K. Paulson; Todd A. Kaprak; Christopher J. Gresk; Douglas M. Fast; Mike T. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

The plasma protein binding of celecoxib was determined for animals and humans using in vitro and ex vivo methods. Eight, healthy, human volunteers (three male, five female, 20-39 years) received celecoxib (600 mg) BID for 7 days, blood samples were collected and concentrations of bound and unbound c