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Interspecies Pharmacokinetic Comparisons and Allometric Scaling of Napsagatran, a Low Molecular Weight Thrombin Inhibitor

✍ Scribed by Thierry Lavé; Renée Portmann; Gabriela Schenker; Alvaro Gianni; Alberto Guenzi; Maria-Angela Girometta; Monique Schmitt


Book ID
111769727
Publisher
Pharmaceutical Press
Year
1999
Tongue
English
Weight
151 KB
Volume
51
Category
Article
ISSN
2042-7158

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Pharmacokinetics, excretion, and metabolism of inogatran, a low-molecular-weight thrombin inhibitor, were studied in the rat, dog, and cynomolgus monkey. After intravenous administration the half-life was short in all three animal species, due to a small volume of distribution and a relatively high