Animal pharmacokinetics of inogatran, a
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Ulf G. Eriksson; Lars Renberg; Ulf Bredberg; Ann-Catrine Teger-Nilsson; Carl Gun
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Article
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1998
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John Wiley and Sons
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English
⚖ 233 KB
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Pharmacokinetics, excretion, and metabolism of inogatran, a low-molecular-weight thrombin inhibitor, were studied in the rat, dog, and cynomolgus monkey. After intravenous administration the half-life was short in all three animal species, due to a small volume of distribution and a relatively high