The antimalarial drug, halofantrine, is chiral and is administered clinically as the racemate. In order to define the pharmacokinetic properties of halofantrine enantiomers in the rat, male Sprague-Dawley rats (264-311 g) were given halofantrine HCl orally (n = 5; 14 mg/kg) or intravenously (i.v.) (
Interspecies correlation of the pharmacokinetics of erythromycin, oleandomycin, and tylosin
β Scribed by Gwen S. Duthu
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 439 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-3549
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## Abstract ## BACKGROUND. Ifosfamide is a chemotherapeutic agent that requires cytochrome P450 3A (CYP3A) for bioactivation and metabolism. To the authors' knowledge, the correlation between dose, pharmacokinetics, CYP3A, and toxicity has not been fully evaluated. A randomized Phase II trial was