interruptions adversely affect local control and survival with hyperfractionated radiation therapy of carcinomas of the upper respiratory and digestive tracts new evidence for accelerated proliferation from radiation therapy oncology group protocol 8313
✍ Scribed by James D. Cox; Thomas F. Pajak; Victor A. Marcial; Lawrence Coia; Mohammed Mohiuddin; Karen K. Fu; Hosny M. Selim; Roger W. Byhardt; Philip Rubin; Hernando G. Ortiz; Linda Martin
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 474 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Hyperfractionated radiation therapy (HFX) attempts to overcome tumor proliferation during treatment by permitting higher total doses in the same overall time as standard fractionation. Whereas interruptions, including splits, reduce local control with standard fractionation in carcinoma of the upper respiratory and digestive tracts, HFX might compensate for interruptions. Patients were randomized to receive total doses of 6720, 7200, 7680, and 8160 cGy, using 120 cGy twice daily, 5 days per week. Those analyzed received & 4% of assigned total dose and lived 90 days or more. Treatment was completed within 5 days of the time specified for each treatment arm in 233 patients; 48, 80, and 131 patients had delays 14, 10, and 5 days or more, respectively. Locoregional