✦ LIBER ✦

Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus

✍ Scribed by Kendo Kiyosawa; Takeshi Sodeyama; Eiji Tanaka; Yukio Gibo; Kaname Yoshizawa; Yoshiyuki Nakano; Seiichi Furuta; Yoshihiro Akahane; Kusuya Nishioka; Robert H. Purcell; Harvey J. Alter

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 523 KB
Volume: 12
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840120409

No coin nor oath required. For personal study only.

✦ Synopsis

To clarify the relationship between hepatitis C virus infection and the development of hepatocellular carcinoma as sequelae of non-A, non-B posttransfusion hepatitis, 231 patients with chronic non-A, non-B hepatitis (96 with chronic hepatitis, 81 with cirrhosis and 64 with hepatocellular carcinoma) were analyzed for antibody to hepatitis C virus and were compared with 126 patients with chronic hepatitis B (60 with chronic hepatitis, 46 with cirrhosis and 29 with hepatocellular carcinoma). Antibody to hepatitis C virus was detected in 89.6%, 86.4% and 94.4% of patients with non-A, non-B hepatitkrelated chronic hepatitis, cirrhosis and hepatocellular carcinoma, respectively, compared with 6%, 17.4% and 34.6% with similar diseaaea related to hepatitis B. A history of transfusion was documented in 52%, 33% and 42% of anti-hepatitis C virugpositive cases of chronic hep atitis, cirrhosis and hepatocellular carcinoma. The mean intervals between the date of tranefaeion and the date of diagnosis of anti-hepatitis C virus-positive chronic hepatitis, cirrhosis and hepatoeellular car- cinoma were 10, 21.2 and 29 yr, respectively. In 21 patients with tradbsion-associated hepatocellular carcinoma, anti-hepatitis C virus wae pweent in each serial sample available for testing, including samples obtained up to 14 yr before the diagnosis of hepatocellular carcinoma. These data suggest the slow, sequential progreesion from acute hepatitis C virusrelated non-A, non-B hepatitis through chronic hep atitis and cirrhosis to hepatocellular carcinoma and support a c a d association between hepatitis C virus and hepatocellular carcinoma. (HEPATOLOGY 1990; 12: 671875.)

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