✦ LIBER ✦
Interrelations between electronic structure and spatial geometry of specific ligands in the functioning active site of some pyridoxal-p-dependent enzymes
✍ Scribed by V. P. Almazov; Yu. V. Morozov; F. A. Savin; B. S. Sukhareva
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 419 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0020-7608
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✦ Synopsis
Abstract
Using a spectrokinetic approach the absorption spectra of the short‐lived transient products in the enzymatic reaction of the glutamate decarboxylase with natural substrate are determined for the first time. The quantum‐chemical calculations of the electronic structure and spectra of various ionic species of numerous vitamin B~6~ derivatives allowed a hypothesis on the nature of the intermediate products detected to be suggested. A model of the enzyme functioning taking into account the charge equilibria and some electronic–conformational relations is proposed.