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Interplay of Transporters and Enzymes in Drug and Metabolite Processing

✍ Scribed by Pang, K. Sandy; Maeng, Han-Joo; Fan, Jianghong


Book ID
120547620
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
1018 KB
Volume
6
Category
Article
ISSN
1543-8384

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Induction of drug metabolism enzymes and
✍ Matthew D. Merrell; Lisa M. Augustine; Angela L. Slitt; Nathan J. Cherrington πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 325 KB

## Abstract Coordinate regulation of Phase‐I and ‐II enzymes with xenobiotic transporters has been shown after treatment with microsomal enzyme inducers. The chemopreventive agent oltipraz (OPZ) induces Phase‐I and ‐II drug‐metabolizing enzymes such as CYP2B and NQO1. The purpose of this study was