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Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas

✍ Scribed by Ligia A. Paiva; Clarissa M. Maya-Monteiro; Christianne Bandeira-Melo; Patricia M.R. Silva; Marcia C. El-Cheikh; Anderson J. Teodoro; Radovan Borojevic; Sandra A.C. Perez; Patricia T. Bozza

Book ID: 118426320
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 899 KB
Volume: 1801
Category: Article
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2010.08.014

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## Abstract ## Background/aims Transforming growth factor β (TGFβ1) is considered the key mediator in the process of liver fibrosis. The purpose of this investigation was to evaluate the activity of ribozymes against TGFβ1 in a cell‐free system and activated hepatic stellate cells (HSCs), and anti