Interplay between 20S proteasomes and pr
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Manila Amici; Valentina Cecarini; Massimiliano Cuccioloni; Mauro Angeletti; Simo
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Article
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2010
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John Wiley and Sons
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English
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## Abstract Scrapie is a transmissible spongiform encephalopathy affecting the central nervous system in sheep. The key event in such neurodegeneration is the conversion of the normal prion protein (PrP^C^) into the pathological isoform (PrP^Sc^). Misfolded prion proteins are normally degraded by t