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Interplay between genetic and epigenetic factors governs common fragile site instability in cancer

✍ Scribed by Ozeri-Galai, Efrat; Tur-Sinai, Michal; Bester, Assaf C.; Kerem, Batsheva

Book ID
126836034
Publisher
Springer
Year
2014
Tongue
English
Weight
402 KB
Volume
71
Category
Article
ISSN
1420-682X

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## Abstract The common fragile site, FRA3B, has been shown to be a site of frequent homozygous deletions in some cancers, resulting in loss of expression of the associated __FHIT__ gene. It has been proposed that __FHIT__ is a tumor suppressor gene that is inactivated as a result of the instability