✦ LIBER ✦

Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb

✍ Scribed by Barboric, Matjaz; Kohoutek, Jiří; Price, Jason P; Blazek, Dalibor; Price, David H; Peterlin, B Matija

Book ID: 110031271
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 712 KB
Volume: 24
Category: Article
ISSN: 0261-4189
DOI: 10.1038/sj.emboj.7600883

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Inhibition of P-TEFb (CDK9/Cyclin T) Kin

Inhibition of P-TEFb (CDK9/Cyclin T) Kinase and RNA Polymerase II Transcription by the Coordinated Actions of HEXIM1 and 7SK snRNA

✍ Jasper H.N Yik; Ruichuan Chen; Rieko Nishimura; Jennifer L Jennings; Andrew J Li 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 544 KB

U30 of 7SK RNA Forms a Specific Photo-cr

U30 of 7SK RNA Forms a Specific Photo-cross-link with Hexim1 in the Context of Both a Minimal RNA-binding site and a Fully Reconstituted 7SK/Hexim1/P-TEFb Ribonucleoprotein Complex

✍ François Bélanger; Huricha Baigude; Tariq M. Rana 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 585 KB

T-loop phosphorylated Cdk9 localizes to

T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes

✍ Eugene C. Dow; Hongbing Liu; Andrew P. Rice 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 560 KB

## Abstract P‐TEFb functions to induce the elongation step of RNA polymerase II transcription by phosphorylating the carboxyl‐terminal domain of the largest subunit of RNA polymerase II. Core P‐TEFb is comprised of Cdk9 and a cyclin regulatory subunit, with Cyclin T1 being the predominant Cdk9‐asso