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Interphase cytogenetics in chronic lymphocytic leukemia

✍ Scribed by Jose A. Garcia-Marco; Cathy M. Price; Daniel Catovsky

Book ID
114136153
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
730 KB
Volume
94
Category
Article
ISSN
0165-4608

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The chromosomal translocation t(11;14)(q13;q32) fuses the IGH and CCND1 genes and leads to cyclin D1 overexpression. This genetic abnormality is the hallmark of mantle cell lymphoma (MCL), but is also found in some cases of atypical chronic lymphocytic leukemia (CLL), characterized by a poor outcome