Internuclear ophthalmoplegia with narcotic overdosage

✍ Scribed by Rif S. El-Mallakh

• Book ID: 101465371
• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 126 KB
• Volume: 20
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.410200122

✦ Synopsis

Immunolocalization of y-enolase using specific mAb in a wide range of nonneuronal tumors limits its use as a marker. Great care should be exercised in interpreting immunocytochemical studies to demonstrate y-enolase in tissue sections.

Several authors have already speculated on the functional importance of y-enolase expression in nonneuronal tissues. The most striking differences between y-enolase and a-and p-enolases are that the former is more stable in the presence of high concentrations of chloride ions and that its activity suffers less from the inhibitory effect of excess substrate. We submit that some cells (not strictly neuronal in origin) can express y-enolase under appropriate conditions, enabling them to keep up with extra energy demands.