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Minocycline, a semi-synthetic tetracycline derivative, has been shown to be neuroprotective in some forms of adult ischemic insult and has been shown to protect the neonatal rat brain following hypoxiaischemia (H-I). We sought to determine whether minocycline could provide long-term protection of spatial learning and memory performance in rats after neonatal H-I exposure. Postnatal day (PD) 7 rats underwent H-I (unilateral carotid ligation and 8% O 2 for 2 hr) or sham control treatment. Immediately following H-I exposure, neonates were treated with intraperitoneal injection of minocycline (45mg/kg) or vehicle (phosphate-buffered saline). Treated and sham rats were behaviorally tested for spatial memory performance in the Morris water maze task as adults (PN65-90). Testing was composed of six acquisition trials and one probe trial per day for 11 days. Probe time (a measure of spatial memory performance) of minocyline-treated rats did not significantly differ from that of sham control rats ( p > .05). Probe time of vehicle-treated rats was significantly reduced compared to that of sham control rats ( p < .05). Results indicate that a single treatment with minocycline significantly protects against spatial memory deficits induced by neonatal H-I, even into adulthood. [
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