International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers
✍ Scribed by Paul Kirk; Taigang He; Lisa J. Anderson; Michael Roughton; Mark A. Tanner; Wynnie W.M. Lam; Wing Y. Au; Winnie C.W. Chu; Godfrey Chan; Renzo Galanello; Gildo Matta; Mark Fogel; Alan R. Cohen; Ru San Tan; Kevin Chen; Ivy Ng; Angie Lai; Suthat Fucharoen; Jiraporn Laothamata; Suporn Chuncharunee; Sutipong Jongjirasiri; David N. Firmin; Gillian C. Smith; Dudley J. Pennell
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 148 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose:
To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.
Materials and Methods:
Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed.
Results:
Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver.
Conclusion:
These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well‐defined and approved imaging and analysis techniques are used. J. Magn. Reson. Imaging 2010;32:315–319. © 2010 Wiley‐Liss, Inc.