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Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

✍ Scribed by Bedinger, Patricia; Moriarty, Ann; von Borstel, Robert C.; Donovan, Nancy J.; Steimer, Kathelyn S.; Littman, Dan R.


Book ID
109754837
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
560 KB
Volume
334
Category
Article
ISSN
0028-0836

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CD5 functions as a negative regulator of TCR signaling during intrathymic T cell development, but it is not known if this negative regulatory function requires CD5 engagement of an extracellular ligand. The present study has specifically examined the role of the CD5 extracellular domain in T cell de