Internalization of glucagon-like peptide-1(7–36)amide in rat insulinoma cells
✍ Scribed by R. Göke; G. Richter; B. Göke; M. Trautmann; R. Arnold
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 610 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0372-8722
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Insulin-like eects of glucagon-like peptide-1(7-36)amide (GLP-1) in rat liver, skeletal muscle and fat, and also the presence of GLP-1 receptors in these extrapancreatic tissues, have been documented. In skeletal muscle and liver, the action of GLP-1 is not associated with an activation of adenylate
## Abstract The conformational changes of free, monomeric glucagon‐like peptide‐1‐(7–36)‐amide (GLP‐1) in aqueous solution with increasing concentrations of 2,2,2‐trifluoroethanol (TFE) were monitored by NMR spectroscopy. It was found that GLP‐1 gradually assumes a stable, single‐stranded helical s